Solving MRI inversion problems for quantitative multi-parameter estimation
Topic: Inversion problems, regularization, bSSFP, MRI simulations, data processing and analysis, complex systems.
Who: Students with a background in mathematics, computer science, physics, electrical or bio(medical) engineering. Everyone who is interested in new and creative mathematical models and solutions, regularization, computer simulations and parameter estimation on real experimental data.
Background: In quantitative MRI the dynamics of a complex physical system is described by the combination of a set of physical equations leading to a certain kind of quantitative model or quantitative map. Those respective models/maps are used for the quantification of e.g. water-fat fractions or T1- and T2-time. By trying to map acquired/simulated data to the quantitative parameter of interest, inversion problems are frequently encountered. Depending on the problem, inversions can be challenging to solve. The challenge can either originate on the sparsity of acquired data or also on the mathematical model itself. The quantification of multi-Compartment systems in MRI exhibits a lot of inversion operations, where some problems arise as ambiguities or so called “ill-posed problems”. Sometimes it is possible to find solutions of the inversion by constraining the system to boundary conditions, by reducing the complexity or dimensionality of the model or bring it in another mathematical formulation. Some of those problems are not well understood yet and their solution is key for a robust quantification of multi-compartment systems in MRI.
Project: In this project, we aim to first identify a system with known dynamics, and then develop a solution for the identified system. The prospective student will investigate inversion problems arising in parameter quantification in multi-compartment systems, like water and fat, with special focus on the bSSFP-sequence. We will investigate whether a problem can be solved analytically/numerically by an unambiguous mathematical representation or develop a regularized inverse problem-solving technique. Elaborated solutions will be tested in simulations (Bloch-Simulation) and on real experimental data.
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Prof. Jessica Bastiaansen will be joining the Annual Meeting Program Committee (AMPC) of the ISMRM
Jessica was invited to serve on the Annual Meeting Programming Committee (AMPC) of the International Society for Magnetic Resonance in Medicine (ISMRM) from 2024. “It is true honour to be asked, and I look forward to contribute!”. The annual meeting attracts over 5000 scientists in the field of MRI. The Annual Meeting Program Committee is […]
Dr. Rahel Heule presented about asymmetries in the brain at 9.4T
Dr Rahel Heule from the Max Planck Institute in Tuebingen and the children’s hospital in Zuerich visited our imaging center in Bern. She gave a seminar entitled “Asymmetries in the Brain: A Methodological Exploration of bSSFP MRI in Neuroimaging at 3T and 9.4T“. Our belief in bSSFP methods to uncover novel biomarkers have only been […]
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Prof. Bastiaansen joins the editorial board of Circulation: Cardiovascular Imaging
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Dr. Eva Peper hops on the editorial board of JMRI – Congratulations!
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For our MRI developments, that build on the use of phase-cycled bSSFP MRI acquisitions to determine tissue fractions within a voxel, a US Patent was granted on May 22nd 2022. Congratulations to the inventors Giulia Rossi, Tobias Kober, Tom Hilbert and Jessica Bastiaansen. These exciting findings form the basis of the research of QIS LAB, […]
Testing Coffins for Team Building
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Jessica Bastiaansen talked about “Tips and Hurdles in grant applications” in beautiful Thessaloniki in Greece. The session was organized during the EMIM, the annual meeting of the European Society for Molecular Imaging (ESMI).